Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.40 |
| ▸ | MMP9 | P14780 | 8/20 | 0.40 |
| ▸ | MMP3 | P08254 | 8/20 | 0.40 |
| ▸ | MMP13 | P45452 | 7/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 8/20 | 0.36 |
| ▸ | MMP7 | P09237 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 5/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952033 | 0.85 | MMP3 (0.40) | MMP2MMP9MMP3MMP13PLA2G7 | |
| SCHEMBL7221727 | 0.83 | MMP2 (0.37) | MMP2MMP9MMP3MMP13PLA2G7 | |
| SCHEMBL6952582 | 0.82 | MMP2 (0.38) | MMP2MMP9MMP3MMP13PLA2G7 | |
| SCHEMBL6947897 | 0.81 | CPB2 (0.48) | MMP2MMP9MMP3MMP13PLA2G7 | |
| SCHEMBL7028144 | 0.79 | MMP2 (0.44) | MMP2MMP9MMP3MMP13PLA2G7 | |
| SCHEMBL7974062 | 0.78 | MMP2 (0.31) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7078769 | 0.77 | MMP2 (0.36) | MMP2MMP9MMP3MMP13PLA2G7 | |
| SCHEMBL7977189 | 0.76 | PLA2G7 (0.39) | MMP2MMP9MMP3MMP13PLA2G7 | |
| SCHEMBL4818302 | 0.76 | PLA2G7 (0.43) | MMP2MMP9MMP3MMP13PLA2G7 | |
| SCHEMBL4822556 | 0.76 | PLA2G7 (0.43) | MMP2MMP9MMP3MMP13PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030836-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2003-01-29 | — | — | EP | disclosed |
| US-6187924-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TUMOR NECROSIS FACTOR-ALPHA-MEDIATED DISEASES | DARWIN DISCOVERY, LTD. (GB) | 2001-02-13 | — | — | US | disclosed |
| EP-1030836-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | Darwin Discovery Limited (GB) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024399-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |