Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 6/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951821 | 0.87 | ALDH1A1 (0.46) | ALOX5AKR1B10AKR1B1HDAC1ALDH1A1 | |
| SCHEMBL6953935 | 0.84 | ALOX5 (0.47) | ALOX5AKR1B10AKR1B1HDAC1HDAC6 | |
| SCHEMBL6953931 | 0.84 | ALOX5 (0.47) | ALOX5AKR1B10AKR1B1HDAC1HDAC6 | |
| SCHEMBL6946513 | 0.77 | MAPT (0.44) | ALOX5HDAC1HDAC6 | |
| SCHEMBL6951815 | 0.76 | ALOX5 (0.45) | ALOX5AKR1B10AKR1B1HDAC1ALDH1A1 | |
| SCHEMBL6952475 | 0.75 | HDAC1 (0.36) | ALOX5AKR1B10AKR1B1HDAC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6949937 | 0.74 | MAPT (0.42) | ALOX5HDAC1ALDH1A1HDAC6 | |
| SCHEMBL14848989 | 0.73 | ESR1 (0.52) | ALOX5AKR1B10AKR1B1ALDH1A1MAPK1 | |
| SCHEMBL6950054 | 0.73 | KDM5A (0.50) | HDAC1ALDH1A1HDAC6 | |
| SCHEMBL6945589 | 0.73 | TUBB4A (0.46) | ALOX5HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |