Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947176 | 0.81 | MAPT (0.38) | HDAC1MAPTNPC1RAB9AHDAC6 | |
| SCHEMBL6945352 | 0.80 | HDAC6 (0.39) | HDAC1MAPTNPC1RAB9AHDAC6 | |
| SCHEMBL6951797 | 0.79 | MAPT (0.37) | HDAC1MAPTNPC1RAB9AHDAC6 | |
| SCHEMBL6953939 | 0.75 | ALOX5 (0.47) | HDAC1HDAC6P2RY12AKR1B10AKR1B1 | |
| SCHEMBL6951821 | 0.73 | ALDH1A1 (0.46) | HDAC1MAPTNPC1RAB9AHDAC6 | |
| SCHEMBL6951815 | 0.66 | ALOX5 (0.45) | HDAC1MAPTNPC1RAB9AHDAC6 | |
| SCHEMBL6953931 | 0.66 | ALOX5 (0.47) | HDAC1HDAC6P2RY12AKR1B10AKR1B1 | |
| SCHEMBL6953935 | 0.66 | ALOX5 (0.47) | HDAC1HDAC6P2RY12AKR1B10AKR1B1 | |
| SCHEMBL6952472 | 0.65 | HDAC1 (0.40) | HDAC1MAPTRAB9AHDAC6PTGS2 | |
| SCHEMBL6945589 | 0.65 | TUBB4A (0.46) | MAPTNPC1RAB9AHDAC6ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |