Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223686 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL10513349 | 0.81 | PBRM1 (0.54) | SMN1; SMN2HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL15201237 | 0.81 | PARP1 (0.47) | SMN1; SMN2HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL10941605 | 0.80 | CYP2C9 (0.53) | SMN1; SMN2HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL30733928 | 0.79 | PARP1 (0.46) | SMN1; SMN2HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL5215323 | 0.79 | ALDH1A1 (0.56) | SMN1; SMN2HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL11732492 | 0.77 | GAA (0.55) | HSD17B10ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL15100604 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL15201680 | 0.77 | IDO1 (0.50) | ALDH1A1MEN1KMT2ANPC1PARP1 | |
| SCHEMBL526662 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2HSD17B10ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154996-B1 | AROYL AMINOACYL PYRROLES FOR USE IN THE TREATMENT OF NEUROPATHIC PAIN | ORTHO MCNEIL PHARM INC (US) | 2003-11-05 | — | — | EP | disclosed |
| US-6369228-B2 | ANTICONVULSANTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-04-09 | — | — | US | disclosed |
| US-20010044452-A1 | Aroyl aminoacyl pyrroles for use in the treatment of neuropathic pain | CARSON JOHN R (US) | 2001-11-22 | — | — | US | disclosed |
| EP-1154996-A2 | AROYL AMINOACYL PYRROLES FOR USE IN THE TREATMENT OF NEUROPATHIC PAIN | Ortho-McNeil Pharmaceutical, Inc. (US) | 2001-11-21 | — | — | EP | disclosed |
| US-6191142-B1 | Aroyl aminoacyl pyrroles for use in the treatment of neuropathic pain | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-02-20 | — | — | US | disclosed |
| WO-2000048584-A2 | AROYL AMINOACYL PYRROLES FOR USE IN THE TREATMENT OF NEUROPATHIC PAIN | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-08-24 | — | — | WO | disclosed |
| US-5332736-A | Anti-convulsant aroyl aminoacylpyrroles | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044452-A1 | Aroyl aminoacyl pyrroles for use in the treatment of neuropathic pain | OPRL1, AADAT, OPRK1 | SMN1; SMN2 1076/4885HSD17B10 1851/4885ALDH1A1 1044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.