Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | HTR6 | P50406 | 10/20 | 0.48 |
| ▸ | KHK | P50053 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955312 | 0.85 | HTR6 (0.48) | DRD2HTR6KHKKCNH2HTR1A | |
| SCHEMBL6954562 | 0.83 | DRD2 (0.56) | DRD2HTR6KHKKCNH2HTR1A | |
| SCHEMBL6583508 | 0.81 | HTR6 (0.54) | HTR6KHKKCNH2HTR1ADRD3 | |
| SCHEMBL6961931 | 0.80 | KCNH2 (0.69) | DRD2KCNH2HTR1ADRD3 | |
| SCHEMBL9462735 | 0.80 | HTR6 (0.68) | HTR6KHKKCNH2HTR1ADRD3 | |
| SCHEMBL6962241 | 0.78 | DRD2 (0.49) | DRD2HTR6KHKKCNH2HTR1A | |
| SCHEMBL6962346 | 0.77 | HTR1A (0.50) | DRD2HTR6KHKKCNH2HTR1A | |
| Hydrochloric Acid SCHEMBL27751697 | 0.76 | HTR6 (0.61) | DRD2HTR6KCNH2HTR1A | |
| SCHEMBL6580736 | 0.76 | HTR6 (0.61) | DRD2HTR6KCNH2HTR1A | |
| SCHEMBL9150236 | 0.76 | HTR6 (0.50) | HTR6KHKHTR1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602889-B1 | 5-heteroaryl substituted indoles | H. LUNDBECK A.S. (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-1068198-B1 | 5-HETEROARYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2003-05-28 | — | — | EP | disclosed |
| EP-1068198-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H.Lundbeck A/S (DK) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999046259-A1 | 5-HETEROARYL SUBSTITUTED INDOLES | H. LUNDBECK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |