Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PTGIR | P43119 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 13/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 13/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 13/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952923 | 0.79 | PTGS1 (0.54) | HTR1DHTR1BPTGS1PTGS2PTGIR | |
| SCHEMBL6673352 | 0.68 | PTGS1 (0.53) | PTGS1PTGS2 | |
| SCHEMBL6642062 | 0.67 | PTGS1 (0.53) | PTGS1PTGS2 | |
| SCHEMBL6672311 | 0.67 | PTGS1 (0.53) | PTGS1PTGS2 | |
| SCHEMBL6984374 | 0.64 | PTGS2 (0.53) | PTGS1PTGS2 | |
| SCHEMBL6668333 | 0.63 | PTGS1 (0.52) | PTGS1PTGS2 | |
| SCHEMBL21519638 | 0.62 | ADRA2A (0.61) | HTR1DHTR1BPTGIRADRA2AADRA2B | |
| SCHEMBL6671972 | 0.62 | PTGS1 (0.47) | PTGS1PTGS2 | |
| SCHEMBL1036359 | 0.61 | ADRA2A (0.78) | PTGIRADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL11657839 | 0.60 | ADRA2A (0.59) | PTGIRADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904270-B1 | DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS | UNIV VANDERBILT (US) | 2003-09-24 | — | — | EP | disclosed |
| US-5684031-A | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents | THE PROCTER & GAMBLE COMPANY (US) | 1997-11-04 | — | — | US | disclosed |