Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 11/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 11/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6967097 | 0.99 | ADRA1D (0.36) | ADRA1DADRA1AADRA1BFFAR2HTR2C | |
| SCHEMBL6956404 | 0.90 | QPCT (0.34) | ADRA1DADRA1AADRA1BQPCT | |
| SCHEMBL6961569 | 0.90 | QPCT (0.34) | ADRA1DADRA1AADRA1BQPCT | |
| SCHEMBL6965561 | 0.88 | ADRA1A (0.41) | ADRA1DADRA1AADRA1BQPCT | |
| SCHEMBL6958793 | 0.87 | ADRA1D (0.33) | ADRA1DADRA1AADRA1BQPCT | |
| SCHEMBL6958679 | 0.87 | ADRA1A (0.39) | ADRA1DADRA1AADRA1BQPCT | |
| SCHEMBL6964803 | 0.84 | ADRA1A (0.40) | ADRA1DADRA1AADRA1BQPCT | |
| Hydrochloric Acid SCHEMBL6964413 | 0.84 | ADRA1A (0.39) | ADRA1DADRA1AADRA1BQPCT | |
| SCHEMBL6956980 | 0.83 | ADRA1D (0.31) | ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL6960279 | 0.82 | ADRA1D (0.31) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | claimed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | claimed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | claimed |