Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953373 | 0.85 | MEN1 (0.41) | MEN1KMT2AHTTSLC18A3 | |
| SCHEMBL6954026 | 0.85 | SLC18A3 (0.51) | MEN1KMT2AHTTSLC18A3HRH3 | |
| SCHEMBL6952186 | 0.84 | SLC6A3 (0.40) | MEN1KMT2AHTTSLC18A3HRH3 | |
| SCHEMBL6959529 | 0.84 | KMT2A (0.40) | MEN1KMT2AHTTSLC18A3HRH3 | |
| SCHEMBL6960338 | 0.84 | MEN1 (0.43) | MEN1KMT2AHTT | |
| SCHEMBL6951206 | 0.83 | MEN1 (0.39) | MEN1KMT2AHTTHRH3 | |
| SCHEMBL6951299 | 0.82 | NPC1 (0.50) | HTTHRH3 | |
| SCHEMBL6958316 | 0.81 | SLC6A1 (0.38) | MEN1KMT2AHTTSLC18A3 | |
| SCHEMBL7076465 | 0.81 | HRH3 (0.45) | MEN1KMT2AHRH3 | |
| SCHEMBL6041588 | 0.80 | MEN1 (0.41) | MEN1KMT2AHTTSLC18A3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |