Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.34 |
| ▸ | USP5 | P45974 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6957178 | 0.75 | HTR7 (0.34) | HTR7RIPK1USP5HDAC6FFAR2 | |
| SCHEMBL6082708 | 0.70 | MTOR (0.37) | HTR7FFAR2KDM1ATSHRSLC6A9 | |
| SCHEMBL5660885 | 0.70 | MTOR (0.37) | HTR7FFAR2KDM1ATSHRSLC6A9 | |
| SCHEMBL6227914 | 0.70 | MTOR (0.37) | HTR7FFAR2KDM1ATSHRSLC6A9 | |
| SCHEMBL7716875 | 0.69 | HTR7 (0.57) | HTR7KMT2A | |
| SCHEMBL7841196 | 0.69 | TSHR (0.36) | HTR7HDAC6FFAR2KDM1ATSHR | |
| SCHEMBL3339864 | 0.65 | P2RX7 (0.44) | HTR7USP5HDAC6FFAR2KDM1A | |
| SCHEMBL3339870 | 0.65 | P2RX7 (0.44) | HTR7USP5HDAC6FFAR2KDM1A | |
| SCHEMBL3344358 | 0.65 | P2RX7 (0.44) | HTR7USP5HDAC6FFAR2KDM1A | |
| SCHEMBL4083074 | 0.64 | FFAR2 (0.43) | RIPK1USP5HDAC6FFAR2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620815-B1 | Selective antagonists for human alpha 1A receptors; benign prostatic hyperplasia, impotency, cardiac arrhythmia treatment; anticholesterol agents; intraocular pressure reduction | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-09-16 | — | — | US | disclosed |
| EP-0988295-A4 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2003-08-13 | — | — | EP | disclosed |
| US-6159990-A | Oxazolidinones as α1A receptor antagonists | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0988295-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998057940-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |