Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 8/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1274397 | 0.82 | RIPK1 (0.35) | HTR7HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL6227914 | 0.81 | MTOR (0.37) | TSHRHTR7SLC6A9FFAR2KDM1A | |
| SCHEMBL5660885 | 0.81 | MTOR (0.37) | TSHRHTR7SLC6A9FFAR2KDM1A | |
| SCHEMBL6082708 | 0.81 | MTOR (0.37) | TSHRHTR7SLC6A9FFAR2KDM1A | |
| SCHEMBL1274529 | 0.80 | ALDH1A1 (0.42) | HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL6957178 | 0.77 | HTR7 (0.34) | TSHRHTR7HDAC6SLC6A9FFAR2 | |
| SCHEMBL7232423 | 0.76 | MGLL (0.39) | — | |
| SCHEMBL7599925 | 0.74 | CCNC (0.40) | TSHRSLC6A9FFAR2 | |
| SCHEMBL7840377 | 0.73 | HTR7 (0.36) | TSHRHTR7HDAC6KDM1A | |
| SCHEMBL7716875 | 0.70 | HTR7 (0.57) | HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140876-A1 | MORPHOLINONE AND MORPHOLINE DERIVATIVES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035891-A1 | MORPHOLINONE AND MORPHOLINE DERIVATIVES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |