Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PEPD | P12955 | 2/20 | 0.42 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL697248 | 0.84 | LMNA (0.45) | POLBLMNARAB9ASMN1; SMN2PKM | |
| SCHEMBL13041433 | 0.82 | FKBP1A (0.51) | POLBLMNARAB9ASMN1; SMN2PKM | |
| SCHEMBL695502 | 0.80 | ACE (0.48) | POLBLMNARAB9ASMN1; SMN2PKM | |
| SCHEMBL14902190 | 0.79 | POLB (0.52) | POLBLMNARAB9ASMN1; SMN2PKM | |
| SCHEMBL7333522 | 0.77 | POLB (0.54) | POLBLMNARAB9ASMN1; SMN2PKM | |
| SCHEMBL7333530 | 0.77 | POLB (0.54) | POLBLMNARAB9ASMN1; SMN2PKM | |
| SCHEMBL13662643 | 0.77 | FKBP1A (0.55) | POLBLMNARAB9ASMN1; SMN2PKM | |
| SCHEMBL4179454 | 0.77 | FKBP1A (0.55) | POLBLMNARAB9ASMN1; SMN2PKM | |
| SCHEMBL696794 | 0.77 | ALDH1A1 (0.48) | LMNARAB9ASMN1; SMN2PKMFKBP1A | |
| SCHEMBL23135776 | 0.76 | ALDH1A1 (0.54) | POLBLMNARAB9ASMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |