SCHEMBL6956733

SCHEMBL6956733

CC(C)c1cc(N)c(C(C)C)[nH]1

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 0.33
SLC2A1 P11166 1/20 0.33
DAO P14920 1/20 0.31
CDC7 O00311 1/20 0.31
ALDH1A1 P00352 1/20 0.30
GAA P10253 1/20 0.30
ALOX12 P18054 1/20 0.30
HTT P42858 1/20 0.30
HIF1A Q16665 1/20 0.30
NOS3 P29474 1/20 0.30
NOS1 P29475 1/20 0.30
NOS2 P35228 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19868200 0.74
SCHEMBL6961109 0.71 DHFR (0.31) DHFRSLC2A1
SCHEMBL29343748 0.67 DAO (0.45) DAO
SCHEMBL28538547 0.66 PDE2A (0.33)
SCHEMBL10015874 0.65 RAD52 (0.32)
SCHEMBL1465545 0.64 CYP2A6 (0.58) DHFRSLC2A1ALDH1A1GAAHTT
SCHEMBL31735550 0.64 CYP2A6 (0.58) DHFRSLC2A1ALDH1A1GAAHTT
SCHEMBL21282786 0.64 GPR84 (0.41) DHFRSLC2A1DAOALDH1A1GAA
SCHEMBL16380895 0.63 DHFR (0.48) DHFRSLC2A1ALDH1A1
SCHEMBL832810 0.62 GAA (0.46) ALDH1A1GAAALOX12HTTHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1278784-A2 CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS EASTMAN CHEMICAL COMPANY (US) 2003-01-29 EP disclosed
EP-1192189-A2 CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS EASTMAN CHEMICAL COMPANY (US) 2002-04-03 EP disclosed
WO-2001083571-A2 CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS EASTMAN CHEMICAL COMPANY (US) 2001-11-08 WO disclosed
WO-2000050470-A2 CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS EASTMAN CHEMICAL COMPANY (US) 2000-08-31 WO disclosed