Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phosphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphine SCHEMBL5445949 | 0.94 | — | — | |
| SCHEMBL449484 | 0.94 | — | — | |
| SCHEMBL3272408 | 0.89 | — | — | |
| SCHEMBL243876 | 0.89 | — | — | |
| Water SCHEMBL3067491 | 0.89 | — | — | |
| SCHEMBL11209185 | 0.89 | — | — | |
| Water SCHEMBL9056814 | 0.89 | — | — | |
| Potassium Ion SCHEMBL11324588 | 0.89 | CA4 (0.31) | — | |
| SCHEMBL30507 | 0.88 | — | — | |
| SCHEMBL9126752 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040765-A2 | BIOACTIVE BONE GRAFT SUBSTITUTE | Orthovita, INC. (US) | 2009-04-01 | — | — | EP | claimed |
| US-20080187571-A1 | BIOACTIVE BONE GRAFT SUBSTITUTE | ORTHOVITA, INC. (US) | 2008-08-07 | — | — | US | claimed |
| WO-2008002682-A9 | BIOACTIVE BONE GRAFT SUBSTITUTE | ORTHOVITA INC (US) | 2008-02-14 | — | — | WO | claimed |
| WO-2008002682-A2 | BIOACTIVE BONE GRAFT SUBSTITUTE | ORTHOVITA, INC. (US) | 2008-01-03 | — | — | WO | claimed |
| EP-4337272-A1 | FLAT SELF-CURLING SHEET MEMBRANES AND METHODS FOR PRODUCING SAME | Collagen Matrix, Inc. (US) | 2024-03-20 | — | — | EP | disclosed |
| EP-2896411-B1 | Bioactive bone graft substitute | ORTHOVITA INC (US) | 2023-08-30 | — | — | EP | disclosed |
| US-11331191-B2 | Bioactive soft tissue implant and methods of manufacture and use thereof | HOWMEDICA OSTEONICS CORP. (US) | 2022-05-17 | — | — | US | disclosed |
| US-11154638-B2 | Methods for forming scaffolds | HOWMEDICA OSTEONICS CORP. (US) | 2021-10-26 | — | — | US | disclosed |
| EP-3785743-A1 | METHODS FOR FORMING SCAFFOLDS | Howmedica Osteonics Corp. (US) | 2021-03-03 | — | — | EP | disclosed |
| US-20200375744-A1 | Bioactive Soft Tissue Implant and Methods of Manufacture and Use Thereof | HOWMEDICA OSTEONICS CORP. | 2020-12-03 | — | — | US | disclosed |
| EP-3130361-B1 | METHODS FOR FORMING SCAFFOLDS | HOWMEDICA OSTEONICS CORP (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-3072538-B1 | BIOACTIVE FLOWABLE WASH-OUT RESISTANT BONE GRAFT MATERIAL AND METHOD FOR PRODUCTION THEREOF | ORTHOVITA INC (US) | 2019-05-22 | — | — | EP | disclosed |
| US-8303967-B2 | mixture of calcium phosphate, collagen and glass; reabsorption | ORTHOVITA, INC. (US) | 2012-11-06 | — | — | US | disclosed |
| US-20120276164-A1 | IMPLANTABLE PASTE AND ITS USE | BONALIVE BIOMATERIALS OY (FI) | 2012-11-01 | — | — | US | disclosed |
| CN-102711714-A | Implantable paste and use thereof | BONALIVE BIOMATERIALS OY | 2012-10-03 | — | — | CN | disclosed |
| EP-2322134-B1 | Implantable paste and its use | BONALIVE BIOMATERIALS OY (FI) | 2012-09-12 | — | — | EP | disclosed |
| EP-2422822-A1 | Bioactive bone graft substitute | Orthovita, Inc. (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2011058134-A1 | IMPLANTABLE PASTE AND ITS USE | BONALIVE BIOMATERIALS OY (FI) | 2011-05-19 | — | — | WO | disclosed |
| EP-2322134-A1 | Implantable paste and its use | BonAlive Biomaterials Oy (FI) | 2011-05-18 | — | — | EP | disclosed |
| US-20080187571-A1 | BIOACTIVE BONE GRAFT SUBSTITUTE | ORTHOVITA, INC. (US) | 2008-08-07 | — | — | US | disclosed |