Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870402 | 0.79 | CTSS (0.42) | CTSS | |
| SCHEMBL6963901 | 0.77 | ALDH1A1 (0.51) | ALDH1A1TSHRTHRBATML3MBTL1 | |
| SCHEMBL6955052 | 0.77 | ALDH1A1 (0.51) | ALDH1A1TSHRTHRBATML3MBTL1 | |
| SCHEMBL6632647 | 0.74 | CTSS (0.45) | ALDH1A1TSHRTHRBATML3MBTL1 | |
| SCHEMBL6957348 | 0.74 | ALDH1A1 (0.50) | ALDH1A1TSHRTHRBATML3MBTL1 | |
| SCHEMBL5870291 | 0.74 | CTSS (0.53) | CTSS | |
| SCHEMBL5870342 | 0.73 | CTSS (0.35) | ALDH1A1TSHRRECQLSMN1; SMN2CTSS | |
| SCHEMBL7207843 | 0.71 | SMN1; SMN2 (0.39) | ALDH1A1TSHRMAPTRECQLKMT2A | |
| SCHEMBL6702419 | 0.70 | CTSS (0.42) | ALDH1A1CTSS | |
| SCHEMBL6476393 | 0.68 | CTSS (0.49) | SMN1; SMN2CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358174-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057248-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |