SCHEMBL6957348

SCHEMBL6957348

O=C(O)C(COC(=O)N1CCOCC1)C1CCCCC1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
TSHR P16473 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.44
RECQL P46063 1/20 0.43
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
POLB P06746 2/20 0.41
LMNA P02545 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
THRB P10828 1/20 0.40
ATM Q13315 1/20 0.40
MAPT P10636 1/20 0.40
KDM4E B2RXH2 1/20 0.38
PRMT5 O14744 2/20 0.38
WDR77 Q9BQA1 2/20 0.38
CPN1 P15169 2/20 0.38
CPB2 Q96IY4 2/20 0.38
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6955052 0.86 ALDH1A1 (0.51) ALDH1A1TSHRL3MBTL1RECQLKMT2A
SCHEMBL6963901 0.86 ALDH1A1 (0.51) ALDH1A1TSHRL3MBTL1RECQLKMT2A
SCHEMBL6632647 0.82 CTSS (0.45) ALDH1A1TSHRL3MBTL1RECQLPOLB
SCHEMBL6957544 0.74 ALDH1A1 (0.40) ALDH1A1TSHRL3MBTL1RECQLKMT2A
SCHEMBL3951076 0.71 ALDH1A1 (0.55) ALDH1A1L3MBTL1KMT2AMEN1NPSR1
SCHEMBL15148102 0.71 TSHR (0.65) ALDH1A1TSHRL3MBTL1RECQLKMT2A
SCHEMBL6061922 0.70 CTSK (0.47) ALDH1A1L3MBTL1POLBSMN1; SMN2THRB
SCHEMBL6062154 0.70 CTSK (0.44) ALDH1A1L3MBTL1POLBSMN1; SMN2THRB
SCHEMBL6062016 0.70 CTSK (0.47) ALDH1A1L3MBTL1POLBSMN1; SMN2THRB
SCHEMBL4449644 0.69 CTSS (0.44) ALDH1A1TSHRL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1362052-A1 INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES Amura Therapeutics Limited (GB) 2003-11-19 EP disclosed
EP-1358174-A2 INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES Amura Therapeutics Limited (GB) 2003-11-05 EP disclosed
WO-2002057248-A2 INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES AMURA THERAPEUTICS LIMITED (GB) 2002-07-25 WO disclosed
WO-2002057270-A1 INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES AMURA THERAPEUTICS LIMITED (GB) 2002-07-25 WO disclosed