Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565489 | 0.87 | MEN1 (0.44) | L3MBTL1PRKCAGSK3BMEN1KMT2A | |
| SCHEMBL6956116 | 0.82 | LMNA (0.54) | LMNAL3MBTL1XBP1ALDH1A1HPGD | |
| SCHEMBL6951613 | 0.73 | PGR (0.46) | ALDH1A1HPGDSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6644290 | 0.73 | MEN1 (0.41) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7642570 | 0.72 | XBP1 (0.50) | LMNAL3MBTL1HDAC6XBP1ALDH1A1 | |
| SCHEMBL6948825 | 0.70 | MEN1 (0.46) | ALDH1A1SIGMAR1MEN1KMT2A | |
| SCHEMBL1185879 | 0.70 | MEN1 (0.63) | L3MBTL1TACR1OPRM1PRKCAGSK3B | |
| SCHEMBL6953268 | 0.69 | LMNA (0.51) | LMNAL3MBTL1HDAC6XBP1ALDH1A1 | |
| SCHEMBL8119434 | 0.69 | ALDH1A1 (0.46) | LMNAALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL8568029 | 0.69 | MEN1 (0.48) | LMNAL3MBTL1SMN1; SMN2TACR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105388-B1 | N-SUBSTITUTED AZABICYCLOHEPTANE DERIVATIVES, PRODUCTION AND USE THEREOF | BASF AG (DE) | 2003-05-02 | — | — | EP | disclosed |
| US-6458821-B1 | THE NOVEL SUBSTANCES ARE SUITABLE FOR CONTROLLING DISEASES. INTERESTING PROPERTIES AS POTENTIAL NEUROLEPTICS AND ANTIDEPRESSANTS | ABBOTT LABORATORIES | 2002-10-01 | — | — | US | disclosed |