Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | FPR2 | P25090 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961502 | 0.89 | NPC1 (0.58) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL8890569 | 0.86 | KMT2A (0.55) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL6961472 | 0.85 | MAPT (0.49) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL6956414 | 0.85 | MAPT (0.51) | KMT2AMEN1SMN1; SMN2THRBMAPT | |
| SCHEMBL6950919 | 0.85 | LMNA (0.45) | KMT2ASMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL6965216 | 0.84 | THRB (0.46) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL6959624 | 0.83 | MPO (0.51) | NPC1RAB9ASMN1; SMN2THRBMAPT | |
| SCHEMBL6952276 | 0.83 | SMN1; SMN2 (0.56) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL6964188 | 0.81 | MPO (0.51) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL6957950 | 0.81 | LMNA (0.50) | KMT2ANPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540143-B1 | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 2003-02-05 | — | — | EP | disclosed |
| US-5714503-A | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 1998-02-03 | — | — | US | disclosed |
| US-5593993-A | VIRICIDES FOR HTLV TREATMENT OF AIDS | MEDIVIR AB (SE) | 1997-01-14 | — | — | US | disclosed |
| EP-0540143-A2 | Compounds and methods for inhibition of HIV and related viruses | Medivir Aktiebolag (SE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993003022-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES | MEDIVIR AB (SE) | 1993-02-18 | — | — | WO | disclosed |