Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972315 | 0.91 | LMNA (0.46) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6965245 | 0.89 | LMNA (0.42) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6965142 | 0.87 | PDE7A (0.47) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6963335 | 0.86 | LMNA (0.46) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6966276 | 0.86 | MAPT (0.42) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6973379 | 0.84 | CYP3A4 (0.51) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6958268 | 0.84 | LMNA (0.42) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6966094 | 0.82 | LMNA (0.43) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6968103 | 0.81 | MAPT (0.48) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8357964 | 0.76 | SLC6A2 (0.49) | LMNACYP3A4MAPTTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |