Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954030 | 0.85 | MAPT (0.39) | MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL6042649 | 0.81 | ALDH1A1 (0.45) | MAPTALDH1A1TSHRKDM4EPOLB | |
| SCHEMBL6953373 | 0.78 | MEN1 (0.41) | — | |
| SCHEMBL6954026 | 0.78 | SLC18A3 (0.51) | — | |
| SCHEMBL6959529 | 0.77 | KMT2A (0.40) | MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL6952186 | 0.77 | SLC6A3 (0.40) | — | |
| SCHEMBL6960338 | 0.77 | MEN1 (0.43) | TSHR | |
| SCHEMBL22831700 | 0.75 | EPHX2 (0.52) | MAPTALDH1A1KDM4E | |
| SCHEMBL6955374 | 0.75 | MEN1 (0.41) | — | |
| SCHEMBL6952629 | 0.73 | MEN1 (0.35) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |