Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | FABP3 | P05413 | 1/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.51 |
| ▸ | PRNP | P04156 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166558 | 0.95 | SMN1; SMN2 (0.75) | SMN1; SMN2LMNAALDH1A1GAAMAPT | |
| SCHEMBL6957371 | 0.88 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNAALDH1A1GAAMAPT | |
| SCHEMBL6960129 | 0.86 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAALDH1A1GAAMAPT | |
| SCHEMBL11013037 | 0.85 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAALDH1A1GAAMAPT | |
| SCHEMBL7084534 | 0.85 | PRNP (0.53) | SMN1; SMN2LMNAALDH1A1GAAMAPT | |
| SCHEMBL6960507 | 0.85 | PLA2G2A (0.55) | SMN1; SMN2LMNAALDH1A1GAAMAPT | |
| SCHEMBL6955300 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAALDH1A1GAAMAPT | |
| SCHEMBL10617926 | 0.82 | KDM4E (0.65) | SMN1; SMN2LMNAALDH1A1GAAMAPT | |
| SCHEMBL7076894 | 0.82 | F11 (0.51) | SMN1; SMN2LMNAALDH1A1GAAMAPT | |
| SCHEMBL4384277 | 0.82 | ALDH1A1 (0.64) | SMN1; SMN2LMNAALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023267-B1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL SA (CH) | 2003-09-17 | — | — | EP | claimed |
| EP-1023267-B1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL SA (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6482841-B1 | Pyridyl compounds and pharmaceutical compositions containing them | CERMOL S.A. (CH) | 2002-11-19 | — | — | US | disclosed |
| EP-1023267-A1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL S.A. (CH) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999019302-A1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL S.A. (CH) | 1999-04-22 | — | — | WO | disclosed |
| WO-1996033972-A1 | METHODS FOR SYNTHESIZING DIVERSE COLLECTIONS OF PYRIDINES, PYRIMIDINES, 1,4-DIHYDRO DERIVATIVES THEREOF, AND PIPERIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |