Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964092 | 0.92 | SIRT2 (0.38) | SIRT2DRD1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6963779 | 0.80 | SIRT2 (0.39) | SIRT2 | |
| SCHEMBL6963554 | 0.74 | SIRT2 (0.38) | SIRT2 | |
| SCHEMBL7084465 | 0.73 | SIRT2 (0.44) | SIRT2 | |
| SCHEMBL1037984 | 0.71 | SIRT2 (0.40) | SIRT2 | |
| SCHEMBL6960303 | 0.70 | SIRT2 (0.39) | SIRT2 | |
| SCHEMBL8979144 | 0.69 | SIRT2 (0.42) | SIRT2SLC6A4 | |
| SCHEMBL7974401 | 0.68 | SIRT2 (0.43) | SIRT2DRD1 | |
| SCHEMBL1041048 | 0.67 | SIRT2 (0.49) | SIRT2ENPP2 | |
| Hydrochloric Acid SCHEMBL27653628 | 0.66 | KIF11 (0.46) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974584-B1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-01-15 | — | — | EP | disclosed |
| US-6420375-B1 | ANTITUMOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-0974584-A1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-01-26 | — | — | EP | disclosed |