Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | ECE2 | P0DPD6 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959069 | 1.00 | LMNA (0.45) | LMNAKDM4ENPC1RAB9APKM | |
| SCHEMBL6954397 | 0.79 | TBXAS1 (0.56) | TBXAS1CYP19A1MAPTCYP1A2RELA | |
| SCHEMBL6954390 | 0.79 | TBXAS1 (0.56) | TBXAS1CYP19A1MAPTCYP1A2RELA | |
| SCHEMBL8347430 | 0.74 | TBXAS1 (0.68) | LMNATBXAS1CYP19A1MAPTMEN1 | |
| SCHEMBL8347428 | 0.74 | TBXAS1 (0.68) | LMNATBXAS1CYP19A1MAPTMEN1 | |
| SCHEMBL7081073 | 0.74 | TLR8 (0.41) | KDM4ETBXAS1CYP19A1MEN1KMT2A | |
| SCHEMBL7081070 | 0.74 | TLR8 (0.41) | KDM4ETBXAS1CYP19A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL28253387 | 0.73 | TBXAS1 (0.69) | LMNATBXAS1CYP19A1MAPTCYP1A2 | |
| Hydrochloric Acid SCHEMBL9872403 | 0.72 | KDM4E (0.56) | LMNAKDM4ENPC1RAB9APKM | |
| Hydrochloric Acid SCHEMBL7283431 | 0.72 | KDM4E (0.56) | LMNAKDM4ENPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974584-B1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-01-15 | — | — | EP | disclosed |
| US-6420375-B1 | ANTITUMOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-0974584-A1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-01-26 | — | — | EP | disclosed |