Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7081070 | 1.00 | TLR8 (0.41) | TLR8CYP19A1ALDH1A1GAAKDM4E | |
| Fumaric Acid SCHEMBL7086166 | 0.92 | KDM4E (0.51) | ALDH1A1GAAKDM4ETBXAS1MEN1 | |
| Fumaric Acid SCHEMBL7691724 | 0.92 | KDM4E (0.51) | ALDH1A1GAAKDM4ETBXAS1MEN1 | |
| SCHEMBL11077391 | 0.76 | KDM4E (0.51) | ALDH1A1KDM4ETBXAS1MEN1KMT2A | |
| SCHEMBL11077393 | 0.76 | KDM4E (0.51) | ALDH1A1KDM4ETBXAS1MEN1KMT2A | |
| SCHEMBL6963711 | 0.76 | ALDH1A1 (0.50) | TLR8ALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL6963715 | 0.76 | ALDH1A1 (0.50) | TLR8ALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL6959065 | 0.74 | LMNA (0.45) | CYP19A1ALDH1A1KDM4ETBXAS1MEN1 | |
| SCHEMBL6959069 | 0.74 | LMNA (0.45) | CYP19A1ALDH1A1KDM4ETBXAS1MEN1 | |
| SCHEMBL28742385 | 0.73 | SOD1 (0.46) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974584-B1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-01-15 | — | — | EP | disclosed |
| US-6420375-B1 | ANTITUMOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-0974584-A1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-01-26 | — | — | EP | disclosed |