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Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL698719

COc1cc2c(Oc3ccc(NC(=O)c4csc(-c5ccccc5)n4)cc3F)ccnc2cc1OCCCN1CCNCC1.O=C(O)C(F)(F)F

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 20/20 0.70
▸ EGFR P00533 2/20 0.61
▸ KIT P10721 2/20 0.61
▸ KDR P35968 2/20 0.61
▸ FLT3 P36888 2/20 0.61
▸ PDGFRB P09619 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL698255 0.97 MET (0.74) METEGFRKITKDRFLT3
SCHEMBL168013 0.90 MET (0.76) METKDRFLT3
Trifluoroacetic Acid SCHEMBL697610 0.88 MET (0.59) METKITKDR
Trifluoroacetic Acid SCHEMBL703131 0.87 MET (0.61) METKDRFLT3
SCHEMBL168714 0.85 MET (0.63) METKITKDR
SCHEMBL166037 0.84 MET (0.64) METEGFRKITKDRFLT3
Trifluoroacetic Acid SCHEMBL695927 0.82 MET (0.59) METEGFRKITKDRFLT3
SCHEMBL167642 0.79 MET (0.62) METEGFRKITKDRFLT3
Trifluoroacetic Acid SCHEMBL696273 0.79 AXL (0.58) METEGFRKITKDRFLT3
Trifluoroacetic Acid SCHEMBL169050 0.78 MET (0.63) METKITKDRFLT3PDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2609091-B1 PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS LEAD DISCOVERY CENTER GMBH (DE) 2014-11-26 — — EP disclosed
EP-2423208-A1 Pharmaceutically active compounds as Axl inhibitors Lead Discovery Center GmbH (DE) 2012-02-29 — — EP disclosed