Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955594 | 1.00 | CCNE1 (0.35) | CCNE1CDK2CDK1CCNB1CHRNB4 | |
| SCHEMBL19121074 | 1.00 | CCNE1 (0.35) | CCNE1CDK2CDK1CCNB1CHRNB4 | |
| SCHEMBL9973611 | 0.82 | LTA4H (0.31) | — | |
| SCHEMBL9973610 | 0.82 | LTA4H (0.31) | — | |
| SCHEMBL14878202 | 0.81 | CHRNB4 (0.35) | CCNE1CDK2CDK1CCNB1CHRNB4 | |
| SCHEMBL6956713 | 0.80 | IRAK4 (0.34) | IRAK4 | |
| SCHEMBL12202912 | 0.80 | CHRNB4 (0.35) | CCNE1CDK2CDK1CCNB1CHRNB4 | |
| SCHEMBL6960513 | 0.79 | — | — | |
| SCHEMBL6958880 | 0.78 | CHRNB4 (0.37) | CCNE1CDK2CDK1CCNB1CHRNB4 | |
| SCHEMBL6959571 | 0.75 | CHRNB4 (0.37) | CCNE1CDK2CDK1CCNB1CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951051-B2 | Process for producing alkynylketone derivative | SHIONOGI & CO., LTD. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-20170197943-A1 | PROCESS FOR PRODUCING ALKYNYLKETONE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-07-13 | — | — | US | disclosed |
| US-8426589-B2 | Process for production of quinazoline derivative | SHIONOGI & CO., LTD. (JP) | 2013-04-23 | — | — | US | disclosed |
| US-8349857-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2013-01-08 | — | — | US | disclosed |
| US-8202879-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2012-06-19 | — | — | US | disclosed |
| US-20120123114-A1 | QUINAZOLINE DERIVATIVES HAVING TYROSINE KINASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-05-17 | — | — | US | disclosed |
| US-20110257391-A1 | PROCESS FOR PRODUCTION OF QUINAZOLINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2011-10-20 | — | — | US | disclosed |
| US-20090143414-A1 | Quinazoline Derivatives Having Tyrosine Kinase Inhibitory Activity | SHIONOGI & CO., LTD. (JP) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257391-A1 | PROCESS FOR PRODUCTION OF QUINAZOLINE DERIVATIVE | ABL1, MAP2K5, MAP2K2 | CCNE1 573/4885CDK2 65/4885CDK1 143/4885 |
| US-20090143414-A1 | Quinazoline Derivatives Having Tyrosine Kinase Inhibitory Activity | ERBB2, EGFR, ABL1 | CCNE1 631/4885CDK2 198/4885CDK1 392/4885 |
| US-20120123114-A1 | QUINAZOLINE DERIVATIVES HAVING TYROSINE KINASE INHIBITORY ACTIVITY | ERBB2, EGFR, ABL1 | CCNE1 631/4885CDK2 198/4885CDK1 392/4885 |
| US-20170197943-A1 | PROCESS FOR PRODUCING ALKYNYLKETONE DERIVATIVE | PDK4, PDK3, PDK2 | CCNE1 1391/4885CDK2 415/4885CDK1 453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.