Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 8/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844223 | 0.85 | AGER (0.55) | AGERCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6846881 | 0.81 | DRD2 (0.64) | AGERCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6844242 | 0.81 | LMNA (0.60) | AGERCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6839525 | 0.80 | P2RX7 (0.69) | AGERCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6965185 | 0.80 | MAPT (0.52) | AGERCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8340692 | 0.79 | AGER (0.60) | AGERCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6843574 | 0.79 | HTT (0.59) | AGERCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6846700 | 0.78 | AGER (0.55) | AGERCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6839346 | 0.78 | P2RX7 (0.56) | AGERCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8336875 | 0.77 | AGER (0.54) | AGERCYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775118-B1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER (US) | 2003-06-04 | — | — | EP | claimed |