Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084720 | 0.91 | HTR3E (0.40) | PIM1PIM3KCNH2HTR3EHTR3B | |
| SCHEMBL7078779 | 0.89 | ADRA1D (0.35) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6966455 | 0.89 | PIM1 (0.31) | PIM1PIM3 | |
| SCHEMBL6967507 | 0.88 | PIM1 (0.34) | PIM1PIM3TDP1MEN1KMT2A | |
| SCHEMBL5852651 | 0.87 | KCNH2 (0.35) | PIM1PIM3KCNH2HSP90B1TRAP1 | |
| SCHEMBL6957548 | 0.87 | KCNH2 (0.35) | PIM1PIM3KCNH2HSP90B1TRAP1 | |
| SCHEMBL14439807 | 0.86 | KCNH2 (0.38) | KCNH2HSP90B1TRAP1TDP1MEN1 | |
| SCHEMBL6969033 | 0.86 | HSP90B1 (0.32) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Carbamic Acid SCHEMBL667612 | 0.86 | PIM1 (0.36) | PIM1PIM3KCNH2HSP90B1TRAP1 | |
| SCHEMBL6967022 | 0.85 | ADRA1D (0.34) | HSP90B1TRAP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |