Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90B1 | P14625 | 5/20 | 0.32 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.30 |
| ▸ | HTR3B | O95264 | 1/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.30 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077335 | 0.89 | HTR3E (0.40) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6963198 | 0.86 | — | — | |
| SCHEMBL6960591 | 0.86 | PIM1 (0.33) | HSP90B1TRAP1HTR3EHTR3BHTR3A | |
| SCHEMBL7083961 | 0.86 | HSP90B1 (0.31) | HSP90B1TRAP1HSP90AA1HSP90AB1HTR3E | |
| SCHEMBL6957208 | 0.84 | HSP90B1 (0.35) | HSP90B1TRAP1HSP90AA1HSP90AB1 | |
| SCHEMBL6160601 | 0.84 | HSP90B1 (0.33) | HSP90B1TRAP1HSP90AA1HSP90AB1 | |
| SCHEMBL7081246 | 0.84 | HRH4 (0.33) | — | |
| SCHEMBL6961520 | 0.82 | HSP90B1 (0.32) | HSP90B1TRAP1HSP90AA1HSP90AB1 | |
| SCHEMBL6974137 | 0.82 | CYP2C9 (0.32) | HSP90B1TRAP1HSP90AA1HSP90AB1 | |
| SCHEMBL7078779 | 0.82 | ADRA1D (0.35) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |