Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | ALPL | P05186 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10677142 | 0.79 | CYP1A2 (0.40) | CYP1A2CYP2D6ALPLKCNH2ALPI | |
| SCHEMBL2203029 | 0.78 | SLC6A2 (0.41) | CYP1A2CYP2D6ALPLKCNH2ALPI | |
| SCHEMBL10676051 | 0.78 | CYP1A2 (0.39) | CYP1A2CYP2D6ALPLKCNH2ALPI | |
| SCHEMBL2094438 | 0.76 | MAPK1 (0.45) | CYP1A2CYP2D6ALPLKCNH2ALPI | |
| SCHEMBL8646745 | 0.76 | SIGMAR1 (0.48) | CYP1A2CYP2D6ALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL10874338 | 0.74 | ALPL (0.36) | CYP1A2CYP2D6ALPLKCNH2ALPI | |
| SCHEMBL8907082 | 0.74 | MEN1 (0.37) | CYP1A2CYP2D6ALPLKCNH2ALPI | |
| SCHEMBL8648546 | 0.71 | POLB (0.46) | TSHRMAPK1ALDH1A1LMNAKMT2A | |
| SCHEMBL16367727 | 0.67 | SLC18A3 (0.47) | DRD1NFKB1ALDH1A1LMNANPC1 | |
| SCHEMBL1749974 | 0.66 | NOS1 (0.44) | CYP1A2CYP2D6KCNH2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4735959-A | HYPOGLYCEMIC AGENTS | DR. KARL THOMAE GMBH (DE) | 1988-04-05 | — | — | US | claimed |
| EP-0058779-B1 | CARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1984-09-19 | — | — | EP | claimed |
| EP-0058779-A2 | Carboxamides, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1982-09-01 | — | — | EP | claimed |
| US-20030105133-A1 | 4-Substituted piperidine analogs and their use as subtype selective NMDA receptor, antagonists | BIGGE CHRISTOPHER F (US) | 2003-06-05 | — | — | US | disclosed |
| EP-0869791-B1 | 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2003-05-07 | — | — | EP | disclosed |
| US-6448270-B1 | BICYCLIC HETEROARYL ACETYLENES; NEUROPROTECTIVE AGENTS; STROKE, CEREBRAL ISCHEMIA, CENTRAL NERVOUS SYSTEM TRAUMA, HYPOGLYCEMIA, ANXIETY, CONVULSIONS, AMINOGLYCOSIDE ANTIBIOTIC INDUCED HEARING LOSS, MIGRAINES, CHRONIC PAIN, GLAUCOMA | WARNER-LAMBERT COMPANY | 2002-09-10 | — | — | US | disclosed |
| US-6130234-A | 4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists | WARNER-LAMBERT COMPANY (US) | 2000-10-10 | — | — | US | disclosed |
| US-5620988-A | Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1997-04-15 | — | — | US | disclosed |
| EP-0556332-B1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-03-20 | — | — | EP | disclosed |
| EP-0556329-B1 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5466698-A | Substituted tetrahydrophyridines and hydroxypiperidines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1995-11-14 | — | — | US | disclosed |
| WO-1992007831-A1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | disclosed |
| WO-1992007832-A2 | SUBSTITUTED PIPERAZINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | disclosed |
| US-4735959-A | HYPOGLYCEMIC AGENTS | DR. KARL THOMAE GMBH (DE) | 1988-04-05 | — | — | US | disclosed |
| EP-0063826-B1 | 2-AMINO-BENZOIC-ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES OR INTERMEDIATES | Dr. Karl Thomae GmbH (DE) | 1984-12-05 | — | — | EP | disclosed |
| EP-0058779-B1 | CARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS MEDICINES | Dr. Karl Thomae GmbH (DE) | 1984-09-19 | — | — | EP | disclosed |
| EP-0023569-B1 | DERIVATIVES OF CARBOXYLIC ACIDS, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1983-06-22 | — | — | EP | disclosed |
| EP-0063826-A2 | 2-Amino-benzoic-acid derivatives, their preparation and their use as medicines or intermediates | Dr. Karl Thomae GmbH (DE) | 1982-11-03 | — | — | EP | disclosed |
| EP-0058779-A2 | Carboxamides, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1982-09-01 | — | — | EP | disclosed |
| EP-0023569-A1 | Derivatives of carboxylic acids, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105133-A1 | 4-Substituted piperidine analogs and their use as subtype selective NMDA receptor, antagonists | GRIN3B, OPRM1, GRIN3A | CYP1A2 4122/4885CYP2D6 2319/4885ALPL 1729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.