Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | REN | P00797 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13816316 | 0.82 | SYK (0.56) | SYKATMCTSSCTSLCTSB | |
| SCHEMBL825959 | 0.82 | ATM (0.55) | SYKATMCTSSCTSLCTSB | |
| SCHEMBL3825012 | 0.82 | ATM (0.55) | SYKATMCTSSCTSLCTSB | |
| SCHEMBL1186455 | 0.82 | ATM (0.55) | SYKATMCTSSCTSLCTSB | |
| SCHEMBL1185840 | 0.80 | SYK (0.57) | SYKATMCTSSCTSLCTSB | |
| SCHEMBL21974545 | 0.79 | SYK (0.56) | SYKATMCTSSCTSLCTSB | |
| SCHEMBL6973478 | 0.79 | CTSL (0.45) | SYKCTSSCTSLCTSBCTSK | |
| SCHEMBL990242 | 0.77 | CTSS (0.53) | SYKATMCTSSCTSLCTSB | |
| Trifluoroacetic Acid SCHEMBL7348672 | 0.76 | SYK (0.53) | SYKATMRENCTSSCTSL | |
| SCHEMBL7408378 | 0.76 | ATM (0.54) | SYKATMCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869786-B1 | PHARMACEUTICAL COMPOUNDS | LILLY CO ELI (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6376230-B1 | Stereoselective process for producing intermediates of cryptophycins | ELI LILLY AND COMPANY | 2002-04-23 | — | — | US | disclosed |
| WO-2000034252-A2 | PROCESS FOR THE PREPARATION OF CRYPTOPHYCIN DERIVATIVES | ELI LILLY AND COMPANY (US) | 2000-06-15 | — | — | WO | disclosed |