Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966199 | 0.83 | HDAC6 (0.42) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL6966909 | 0.78 | KDM4E (0.43) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL6966094 | 0.78 | LMNA (0.43) | MEN1KMT2AMAPTNPSR1CYP1A2 | |
| SCHEMBL6967573 | 0.76 | HTT (0.47) | MEN1KMT2APOLBMAPTNPSR1 | |
| SCHEMBL8567878 | 0.74 | KDM4C (0.57) | MEN1KMT2AHTR6POLBMAPT | |
| SCHEMBL6963693 | 0.73 | MAPT (0.60) | MEN1KMT2APOLBMAPTNPSR1 | |
| SCHEMBL432366 | 0.72 | HTR6 (0.61) | HTR6POLBMAPTNPSR1PKM | |
| SCHEMBL6972315 | 0.71 | LMNA (0.46) | MEN1KMT2APOLBMAPTNPSR1 | |
| SCHEMBL12205175 | 0.71 | HTR6 (0.66) | MEN1KMT2AHTR6MAPTNPSR1 | |
| SCHEMBL8664733 | 0.71 | ALDH1A1 (0.62) | MEN1KMT2AHTR6POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |