Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.32 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.31 |
| ▸ | CUL4A | Q13619 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8888354 | 0.79 | KDM4E (0.50) | KDM4ELMNAMAPTSLC9A1ALDH1A1 | |
| SCHEMBL6960604 | 0.79 | CUL4A (0.37) | KDM4ELMNAMAPTALDH1A1VCAM1 | |
| SCHEMBL6967817 | 0.75 | LMNA (0.35) | KDM4ELMNAMAPTSLC9A1ALDH1A1 | |
| SCHEMBL6972980 | 0.70 | CUL4A (0.40) | LMNAALDH1A1CUL4A | |
| SCHEMBL5268489 | 0.67 | CUL4A (0.34) | LMNAMAPTALDH1A1CUL4ACA12 | |
| SCHEMBL8094674 | 0.65 | CUL4A (0.43) | KDM4ELMNAMAPTALDH1A1CUL4A | |
| SCHEMBL8887983 | 0.62 | KDM4E (0.46) | KDM4ELMNAMAPTSLC9A1ALDH1A1 | |
| SCHEMBL5198179 | 0.62 | HDAC3 (0.49) | LMNASLC9A1CA12CA1CA2 | |
| SCHEMBL5230123 | 0.61 | CHRNA7 (0.38) | LMNAMAPTALDH1A1CUL4A | |
| SCHEMBL5237648 | 0.61 | STING1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676395-B1 | Substituted N-heteroaroylguanidines, as inhibitors of sodium-hydrogen exchange, as antiarrhythmic agents and as inhibitors of the proliferation of cells | HOECHST AG (DE) | 2003-09-03 | — | — | EP | disclosed |
| EP-0676395-A2 | Substituted N-heteroaroylguanidines, as inhibitors of sodium-hydrogen exchange, as antiarrhythmic agents and as inhibitors of the proliferation of cells | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-10-11 | — | — | EP | disclosed |