Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CUL4A | Q13619 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP14 | P50281 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2305822 | 0.75 | MCL1 (0.51) | ALDH1A1LMNAMAPK1MCL1MAPT | |
| SCHEMBL6972980 | 0.74 | CUL4A (0.40) | CUL4AALDH1A1LMNAMAPK1MMP2 | |
| SCHEMBL6967817 | 0.73 | LMNA (0.35) | ALDH1A1LMNAMAPK1MAPT | |
| SCHEMBL11350166 | 0.73 | CUL4A (0.42) | CUL4ACA12CA1CA2CA9 | |
| SCHEMBL7458964 | 0.72 | ALOX15 (0.48) | ALDH1A1MAPK1MAPT | |
| SCHEMBL28225381 | 0.69 | DAO (0.56) | ALDH1A1LMNAMAPK1MCL1MAPT | |
| SCHEMBL22508643 | 0.69 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPK1MAPT | |
| SCHEMBL10900463 | 0.68 | FBP1 (0.33) | CUL4A | |
| SCHEMBL11351584 | 0.68 | KDM4E (0.39) | CUL4AALDH1A1MAPTMMP2MMP9 | |
| SCHEMBL6960604 | 0.68 | CUL4A (0.37) | CUL4AALDH1A1LMNAMAPTMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836180-B1 | SULFONYL PYRROLIDINES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS DRUGS | SANOFI SA (FR) | 2012-06-13 | — | — | EP | disclosed |
| EP-1836180-A2 | SULFONYL PYRROLIDINES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS DRUGS | sanofi-aventis (FR) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006072393-A2 | SULFONYL PYRROLIDINES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS DRUGS | SANOFI-AVENTIS (DE) | 2006-07-13 | — | — | WO | disclosed |