Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CUL4A | Q13619 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | CCR4 | P51679 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP14 | P50281 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970016 | 0.83 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPK1OPRD1 | |
| SCHEMBL8094674 | 0.80 | CUL4A (0.43) | CUL4AALDH1A1LMNAUSP2HSD17B10 | |
| SCHEMBL6967817 | 0.79 | LMNA (0.35) | ALDH1A1LMNAMAPK1 | |
| SCHEMBL6960604 | 0.77 | CUL4A (0.37) | CUL4AALDH1A1LMNAPIK3CDPIK3CA | |
| SCHEMBL8888381 | 0.75 | LMNA (0.44) | ALDH1A1LMNAMAPK1OPRD1 | |
| SCHEMBL5268489 | 0.74 | CUL4A (0.34) | CUL4AALDH1A1LMNAMAPK1MMP2 | |
| SCHEMBL5200826 | 0.70 | CHRNA1 (0.40) | CUL4AALDH1A1HSD17B10 | |
| SCHEMBL6961979 | 0.70 | KDM4E (0.34) | CUL4AALDH1A1LMNA | |
| SCHEMBL6223306 | 0.67 | CUL4A (0.41) | CUL4AALDH1A1LMNAMAPK1HSD17B10 | |
| SCHEMBL5201465 | 0.67 | RAB9A (0.46) | CUL4ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676395-B1 | Substituted N-heteroaroylguanidines, as inhibitors of sodium-hydrogen exchange, as antiarrhythmic agents and as inhibitors of the proliferation of cells | HOECHST AG (DE) | 2003-09-03 | — | — | EP | disclosed |
| EP-0676395-A2 | Substituted N-heteroaroylguanidines, as inhibitors of sodium-hydrogen exchange, as antiarrhythmic agents and as inhibitors of the proliferation of cells | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-10-11 | — | — | EP | disclosed |