Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MTTP | P55157 | 12/20 | 0.55 |
| ▸ | APOB | P04114 | 10/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8589850 | 0.92 | GAA (0.51) | GAASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL8550062 | 0.87 | KDM4E (0.57) | GAASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL6974148 | 0.79 | MTTP (0.59) | GAASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL7928573 | 0.79 | MTTP (0.59) | GAASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL8210402 | 0.79 | MTTP (0.58) | GAASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL6962881 | 0.79 | MTTP (0.54) | GAASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL8207411 | 0.79 | MTTP (0.60) | GAASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL8213608 | 0.79 | MTTP (0.60) | GAASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL6965797 | 0.79 | MTTP (0.58) | GAASMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL6966884 | 0.79 | APOB (0.61) | GAASMN1; SMN2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |
| US-5919795-A | ATHEROSCLEROSIS THERAPY | PFIZER INC. (US) | 1999-07-06 | — | — | US | disclosed |