Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | APOB | P04114 | 11/20 | 0.48 |
| ▸ | MTTP | P55157 | 10/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962135 | 0.92 | GAA (0.60) | GAASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL8550062 | 0.80 | KDM4E (0.57) | GAASMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL8587342 | 0.79 | APOB (0.52) | APOBMTTP | |
| SCHEMBL8200962 | 0.79 | MTTP (0.52) | APOBMTTP | |
| SCHEMBL9232371 | 0.77 | NAMPT (0.52) | GAASMN1; SMN2ALDH1A1APOBMTTP | |
| SCHEMBL8207493 | 0.77 | ITGB3 (0.55) | GAAMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL6667492 | 0.74 | NOTUM (0.60) | GAASMN1; SMN2MAPTLMNAAPOB | |
| SCHEMBL7076183 | 0.73 | KMT2A (0.58) | SMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL8208394 | 0.73 | APOB (0.49) | APOBMTTPTP53 | |
| SCHEMBL8470621 | 0.73 | APOB (0.47) | APOBMTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-A1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040640-A1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER INC. (US) | 1996-12-19 | — | — | WO | disclosed |