Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.53 |
| ▸ | APOB | P04114 | 9/20 | 0.53 |
| ▸ | MTTP | P55157 | 8/20 | 0.53 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962135 | 0.87 | GAA (0.60) | KDM4EGAAMAPTALDH1A1LMNA | |
| SCHEMBL8589850 | 0.80 | GAA (0.51) | KDM4EGAAMAPTALDH1A1LMNA | |
| SCHEMBL8207411 | 0.79 | MTTP (0.60) | KDM4EGAAMAPTALDH1A1LMNA | |
| SCHEMBL6966884 | 0.79 | APOB (0.61) | KDM4EGAAMAPTALDH1A1LMNA | |
| SCHEMBL8208329 | 0.78 | MTTP (0.57) | KDM4EGAAMAPTALDH1A1LMNA | |
| SCHEMBL8213389 | 0.78 | APOB (0.60) | KDM4EGAAMAPTALDH1A1LMNA | |
| SCHEMBL8210402 | 0.77 | MTTP (0.58) | KDM4EGAAMAPTALDH1A1LMNA | |
| SCHEMBL8199895 | 0.77 | APOB (0.57) | KDM4EGAAMAPTALDH1A1LMNA | |
| SCHEMBL4742408 | 0.77 | MTTP (0.58) | KDM4EGAAMAPTALDH1A1LMNA | |
| SCHEMBL8213404 | 0.77 | MTTP (0.58) | KDM4EGAAMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-A1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040640-A1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER INC. (US) | 1996-12-19 | — | — | WO | disclosed |