Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 16/20 | 0.52 |
| ▸ | MMP1 | P03956 | 5/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969997 | 1.00 | MMP3 (0.52) | MMP3MMP1MMP2CTSK | |
| SCHEMBL6961636 | 0.85 | CTSK (0.59) | MMP3MMP1MMP2CTSK | |
| SCHEMBL6961631 | 0.85 | CTSK (0.59) | MMP3MMP1MMP2CTSK | |
| SCHEMBL6962615 | 0.84 | MMP3 (0.53) | MMP3MMP1MMP2 | |
| SCHEMBL6967414 | 0.83 | MMP3 (0.52) | MMP3MMP1MMP2 | |
| SCHEMBL6964530 | 0.83 | MMP3 (0.52) | MMP3MMP1MMP2 | |
| SCHEMBL6964527 | 0.83 | MMP3 (0.52) | MMP3MMP1MMP2 | |
| SCHEMBL6967976 | 0.81 | MMP1 (0.55) | MMP3MMP1MMP2 | |
| SCHEMBL6967981 | 0.81 | MMP1 (0.55) | MMP3MMP1MMP2 | |
| SCHEMBL6968692 | 0.81 | MMP3 (0.56) | MMP3MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021424-B1 | THIADIAZOLE AMIDE MMP INHIBITORS | UPJOHN CO (US) | 2003-02-26 | — | — | EP | disclosed |
| EP-1021424-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997048688-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |