Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | NT5E | P21589 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 3/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967276 | 0.77 | DRD2 (0.55) | DRD2KCNH2HTR1AHTR1BPIK3CA | |
| SCHEMBL6957221 | 0.77 | KCNH2 (0.51) | KCNH2HTR1AHTR1BNR3C1FAAH | |
| SCHEMBL6957036 | 0.77 | KCNH2 (0.54) | DRD2KCNH2NR3C1PGRMAPT | |
| SCHEMBL6964471 | 0.76 | DRD2 (0.54) | DRD2KCNH2HTR1AHTR1BPIK3CD | |
| SCHEMBL6967960 | 0.76 | KCNH2 (0.50) | DRD2KCNH2HTR1AHTR1BNR3C1 | |
| SCHEMBL6966467 | 0.76 | KCNH2 (0.52) | KCNH2HTR1AHTR1BNR3C1FAAH | |
| SCHEMBL3489735 | 0.75 | CYP1A2 (0.53) | DRD2KCNH2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL6960229 | 0.74 | DRD2 (0.54) | DRD2KCNH2HTR1AHTR1BFAAH | |
| SCHEMBL6966566 | 0.73 | KCNH2 (0.50) | DRD2KCNH2HTR1AHTR1BMAOB | |
| SCHEMBL6961517 | 0.73 | DRD2 (0.54) | DRD2KCNH2HTR1AHTR1BNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602889-B1 | 5-heteroaryl substituted indoles | H. LUNDBECK A.S. (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-1068198-B1 | 5-HETEROARYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2003-05-28 | — | — | EP | disclosed |