Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.48 |
| ▸ | ADH5 | P11766 | 2/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.46 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.46 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.46 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807398 | 0.86 | GRIA1 (0.49) | IDO1NOTUMGRIA1GRIA2GRIA3 | |
| SCHEMBL16151007 | 0.82 | MAPT (0.50) | IDO1NOTUMGRIA1GRIA2GRIA3 | |
| SCHEMBL10902263 | 0.82 | MAPT (0.47) | IDO1ADH5GRIA1GRIA2GRIA3 | |
| SCHEMBL29486349 | 0.79 | ENPP2 (0.50) | IDO1NOTUMADH5GRIA1GRIA2 | |
| SCHEMBL20536197 | 0.79 | CYP19A1 (0.52) | IDO1NOTUMGRIA1GRIA2GRIA3 | |
| SCHEMBL1067164 | 0.79 | LMNA (0.52) | IDO1NOTUMGRIA1GRIA2GRIA3 | |
| SCHEMBL17630137 | 0.79 | GRIA1 (0.46) | IDO1NOTUMGRIA1GRIA2GRIA3 | |
| SCHEMBL1839319 | 0.79 | HPGD (0.51) | IDO1ADH5GRIA1GRIA2GRIA3 | |
| SCHEMBL10800440 | 0.77 | NOTUM (0.63) | IDO1NOTUMADH5CYP19A1CYP11B1 | |
| SCHEMBL7425462 | 0.76 | PDE2A (0.46) | IDO1NOTUMGRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |