Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | VDR | P11473 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | CDC25A | P30304 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974042 | 0.86 | TP53 (0.36) | LMNANPSR1VDRL3MBTL1SLC6A4 | |
| SCHEMBL6968637 | 0.86 | DHODH (0.34) | ALDH1A1MAPTLMNASMN1; SMN2ATM | |
| SCHEMBL6975065 | 0.84 | ALDH1A1 (0.37) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL6975062 | 0.84 | ALDH1A1 (0.37) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL6964826 | 0.83 | VDR (0.36) | KDM4EALDH1A1MAPTLMNAGAA | |
| SCHEMBL6964200 | 0.82 | MAPT (0.37) | KDM4EALDH1A1MAPTLMNAHPGD | |
| SCHEMBL6973368 | 0.82 | ALDH1A1 (0.34) | KDM4EALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL6974223 | 0.82 | ALDH1A1 (0.34) | ALDH1A1MAPTLMNA | |
| SCHEMBL6969836 | 0.82 | HSP90B1 (0.32) | PTGER4 | |
| SCHEMBL6973701 | 0.82 | SMN1; SMN2 (0.40) | MAPK1ALDH1A1MAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |