Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.31 |
| ▸ | CYP21A2 | P08686 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966608 | 0.94 | MAPK14 (0.37) | MAPK14ENPP2 | |
| SCHEMBL6961438 | 0.94 | MAPK14 (0.34) | HRH1HTR6PLK1MAPK14ENPP2 | |
| SCHEMBL6974089 | 0.93 | POLB (0.34) | HRH1HTR6PLK1MAPK14CYP17A1 | |
| SCHEMBL7080045 | 0.91 | MEN1 (0.37) | MEN1KMT2A | |
| SCHEMBL7085356 | 0.91 | ENPP2 (0.36) | MAPK14ENPP2MEN1KMT2A | |
| SCHEMBL7084584 | 0.89 | MAPK14 (0.37) | MAPK14 | |
| SCHEMBL7086072 | 0.88 | HSP90B1 (0.32) | — | |
| SCHEMBL6974410 | 0.87 | MAPK14 (0.36) | MAPK14CYP17A1CYP21A2CYP11B1 | |
| SCHEMBL7080228 | 0.85 | MEN1 (0.34) | PLK1CYP17A1CYP21A2MEN1KMT2A | |
| SCHEMBL6963837 | 0.85 | MEN1 (0.37) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |