SCHEMBL6964218

SCHEMBL6964218

CCn1c(CNC(C)=O)nc(C(C)C)c1Sc1cc(Cl)cc(Cl)c1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.35
HTT P42858 2/20 0.34
POLB P06746 2/20 0.34
ALDH1A1 P00352 2/20 0.34
HPGD P15428 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
SETDB1 Q15047 1/20 0.32
ACSS2 Q9NR19 1/20 0.31
LMNA P02545 1/20 0.31
MALT1 Q9UDY8 1/20 0.31
ALOX15 P16050 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
HSP90B1 P14625 2/20 0.30
HSP90AA1 P07900 1/20 0.30
HSP90AB1 P08238 1/20 0.30
TRAP1 Q12931 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6974137 0.90 CYP2C9 (0.32) HTTLMNAMALT1HSP90B1HSP90AA1
SCHEMBL6975217 0.89 TP53 (0.39) SMN1; SMN2HTTPOLBL3MBTL1LMNA
SCHEMBL6967170 0.87 SMN1; SMN2 (0.35) SMN1; SMN2HTTPOLBALDH1A1HPGD
SCHEMBL6965470 0.86 SETDB1 (0.33) SMN1; SMN2POLBL3MBTL1SETDB1MALT1
SCHEMBL6976137 0.86 HSP90B1 (0.32) HSP90B1HSP90AA1HSP90AB1TRAP1
SCHEMBL7079061 0.86 L3MBTL1 (0.35) SMN1; SMN2HTTPOLBALDH1A1L3MBTL1
SCHEMBL8010363 0.84 HSP90B1 (0.32) ALDH1A1HPGDNPC1RAB9AHSP90B1
SCHEMBL7084307 0.84 SMN1; SMN2 (0.44) SMN1; SMN2HTTPOLBALDH1A1HPGD
SCHEMBL6160601 0.83 HSP90B1 (0.33) ALDH1A1HPGDNPC1RAB9AHSP90B1
SCHEMBL6974554 0.83 MEN1 (0.31) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed