Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13049312 | 1.00 | LMNA (0.58) | LMNAMAPK1CES2CES1HPGD | |
| SCHEMBL8905621 | 1.00 | LMNA (0.58) | LMNAMAPK1CES2CES1HPGD | |
| SCHEMBL8462436 | 0.80 | SRC (0.56) | LMNAMAPK1CES2CES1HSP90AA1 | |
| SCHEMBL409758 | 0.80 | POLB (0.50) | LMNAMAPK1CES2CES1HSP90AA1 | |
| SCHEMBL10443875 | 0.79 | HDAC3 (0.41) | LMNAMAPK1CES2CES1MAPT | |
| SCHEMBL9280967 | 0.79 | BRD4 (0.46) | LMNAMAPK1HPGDMAPTALDH1A1 | |
| SCHEMBL13594127 | 0.78 | PTGS2 (0.48) | LMNAHSP90AA1MAPTGPR55KDM4E | |
| SCHEMBL14723653 | 0.78 | PTGS2 (0.48) | LMNAHSP90AA1MAPTGPR55KDM4E | |
| SCHEMBL12666540 | 0.78 | PTGS2 (0.48) | LMNAHSP90AA1MAPTGPR55KDM4E | |
| SCHEMBL14664123 | 0.77 | SMN1; SMN2 (0.49) | LMNACYP3A4L3MBTL1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220041588-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE AND [1,2,4]TRIAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | FOCHON BIOSCIENCES, LTD. (CN) | 2022-02-10 | — | — | US | disclosed |
| US-8093427-B2 | Construction and screening of solution-phase derived library of fenbufen and ethacrynic acid | NATIONAL TSING HUA UNIVERSITY (TW) | 2012-01-10 | — | — | US | disclosed |
| US-8093427-B2 | Construction and screening of solution-phase derived library of fenbufen and ethacrynic acid | NATIONAL TSING HUA UNIVERSITY (TW) | 2012-01-10 | — | — | US | disclosed |
| US-20110306668-A1 | CONSTRUCTION AND SCREENING OF SOLUTION-PHASE DERIVED LIBRARY OF FENBUFEN AND ETHACRYNIC ACID | NATIONAL TSING HUA UNIVERSITY (TW) | 2011-12-15 | — | — | US | disclosed |
| EP-1095937-B1 | Process for the preparation of trisubstituted oxazoles | OREAL (FR) | 2003-03-12 | — | — | EP | disclosed |
| US-6333414-B1 | BY REACTION OF THIOUREA WITH THE CORRESPONDING DIKETONE ESTER; CARRIED OUT UNDER REACTION CONDITIONS, PARTICULARLY WITH RESPECT TO PH, WHICH ARE INDUSTRIALLY MORE FAVORABLE. | L'ORéAL S.A. (FR) | 2001-12-25 | — | — | US | disclosed |
| EP-1095937-A1 | Process for the preparation of trisubstituted oxazoles | L'OREAL (FR) | 2001-05-02 | — | — | EP | disclosed |
| WO-1998017281-A1 | MONOPHOSPHATE PRODRUGS OF β-L-FD4C AND β-L-FddC AS POTENT ANTIVIRAL AGENTS | VION PHARMACEUTICALS, INC. (US) | 1998-04-30 | — | — | WO | disclosed |
| US-5405860-A | Fungicides | BAYER AKTIENGESELLSCHAFT (DE) | 1995-04-11 | — | — | US | disclosed |
| EP-0379081-A2 | Process for the preparation of 1-hydroxymethyl oxiranes Z-substituted in position 2 | BASF Aktiengesellschaft (DE) | 1990-07-25 | — | — | EP | disclosed |
| US-4912122-A | Triazolyl alkanones or triazolyl-alkanols | BAYER AKTIENGESELLSCHAFT (DE) | 1990-03-27 | — | — | US | disclosed |
| US-4776877-A | FUNGICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1988-10-11 | — | — | US | disclosed |
| US-4772623-A | FUNGICIDES, MICROBIOCIDES, PLANT GROWTH REGULATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1988-09-20 | — | — | US | disclosed |
| US-4582843-A | FUNGICIDES, MICROBIOCIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1986-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220041588-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE AND [1,2,4]TRIAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ABL1, ERBB2 | LMNA 3579/4885MAPK1 109/4885CES2 4368/4885 |
| US-20110306668-A1 | CONSTRUCTION AND SCREENING OF SOLUTION-PHASE DERIVED LIBRARY OF FENBUFEN AND ETHACRYNIC ACID | CYP4F2, ACR, CYP4F3 | LMNA 1898/4885MAPK1 3176/4885CES2 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.