SCHEMBL409758

SCHEMBL409758

CC(C)(C)C(=O)C(c1ccccc1)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
TDP1 Q9NUW8 1/20 0.50
HDAC3 O15379 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC7 Q8WUI4 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC10 Q969S8 1/20 0.48
HDAC11 Q96DB2 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
HDAC9 Q9UKV0 1/20 0.48
HDAC5 Q9UQL6 1/20 0.48
KDM4E B2RXH2 2/20 0.47
ALDH1A1 P00352 1/20 0.47
HTT P42858 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HSP90AA1 P07900 1/20 0.47
MAPT P10636 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23031983 0.86 ACP3 (0.49) POLBL3MBTL1TDP1KDM4EALDH1A1
SCHEMBL23031959 0.84 MEN1 (0.49) ALDH1A1HTTHSP90AA1MAPTGPR55
SCHEMBL23032196 0.83 ACP3 (0.47) POLBL3MBTL1TDP1HDAC3HDAC4
SCHEMBL23031990 0.83 ACP3 (0.47) POLBL3MBTL1TDP1HDAC3HDAC4
SCHEMBL23031967 0.83 CYP2D6 (0.43) ALDH1A1HTTSMN1; SMN2HSP90AA1MAPT
SCHEMBL8462436 0.82 SRC (0.56) POLBL3MBTL1KDM4EALDH1A1HTT
SCHEMBL23031984 0.82 GAA (0.46) POLBHDAC3HDAC4HDAC1HDAC7
SCHEMBL23031177 0.82 TDP1 (0.57) L3MBTL1TDP1ALDH1A1SMN1; SMN2MEN1
SCHEMBL8905621 0.80 LMNA (0.58) L3MBTL1KDM4EALDH1A1HSP90AA1MAPT
SCHEMBL6964334 0.80 LMNA (0.58) L3MBTL1KDM4EALDH1A1HSP90AA1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11732259-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2023-08-22 US disclosed
US-11732259-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2023-08-22 US disclosed
US-20220127613-A1 Functionally-Modified Oligonucleotides And Subunits Thereof SAREPTA THERAPEUTICS INC (US) 2022-04-28 US disclosed
US-11225662-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2022-01-18 US disclosed
US-11208655-B2 Functionally-modified oligonucleotides and subunits thereof SAREPTA THERAPEUTICS, INC. (US) 2021-12-28 US disclosed
US-11072793-B2 DsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups SAREPTA THERAPEUTICS, INC. (US) 2021-07-27 US disclosed
US-20210139897-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS SAREPTA THERAPEUTICS, INC. 2021-05-13 US disclosed
US-20210139896-A1 Peptide Oligonucleotide Conjugates JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2021-05-13 US disclosed
US-20210054007-A1 RECEPTOR INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) 2021-02-25 US disclosed
US-20200277598-A1 Peptide Oligonucleotide Conjugates JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2020-09-03 US disclosed
US-20110306668-A1 CONSTRUCTION AND SCREENING OF SOLUTION-PHASE DERIVED LIBRARY OF FENBUFEN AND ETHACRYNIC ACID NATIONAL TSING HUA UNIVERSITY (TW) 2011-12-15 US disclosed
US-20110300104-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2011-12-08 US disclosed
US-20110250172-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2011-10-13 US disclosed
US-20110178066-A1 Hydroxypiperidine derivatives and uses thereof AVALON PHARMACEUTICALS 2011-07-21 US disclosed
US-20110142798-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2011-06-16 US disclosed
US-20100249111-A1 MULTI-RING COMPOUNDS AND USES THEREOF AVALON PHARMACEUTICALS (US) 2010-09-30 US disclosed
US-20100221214-A1 LINKED DIBENZIMIDAZOLE DERIVATIVES ENANTA PHARMACEUTICALS, INC. 2010-09-02 US disclosed
US-7531539-B2 Pyrrolotriazine kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2009-05-12 US disclosed
US-20090036429-A1 Hydroxypiperidine Derivatives and Uses Thereof AVALON PHARMACEUTICALS 2009-02-05 US disclosed
US-20080045496-A1 PYRROLOTRIAZINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2008-02-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (17 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110300104-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, SLC10A1, EIF2AK2 POLB 682/4885L3MBTL1 2575/4885TDP1 3277/4885
US-20110250172-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, SLC10A1, EIF2AK2 POLB 682/4885L3MBTL1 2575/4885TDP1 3277/4885
US-20200277598-A1 Peptide Oligonucleotide Conjugates SNRPE, SMN1; SMN2, UPF1 POLB 202/4885L3MBTL1 36/4885TDP1 431/4885
US-11208655-B2 Functionally-modified oligonucleotides and subunits thereof RTCB, NSUN3, NSUN2 POLB 159/4885L3MBTL1 28/4885TDP1 441/4885
US-20210054007-A1 RECEPTOR INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF TACR1, TACR2, GPBAR1 POLB 4490/4885L3MBTL1 4883/4885TDP1 4454/4885
US-20210139896-A1 Peptide Oligonucleotide Conjugates SNRPE, SMN1; SMN2, UPF1 POLB 202/4885L3MBTL1 36/4885TDP1 431/4885
US-20110142798-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, SLC10A1, EIF2AK2 POLB 682/4885L3MBTL1 2575/4885TDP1 3277/4885
US-20100249111-A1 MULTI-RING COMPOUNDS AND USES THEREOF TP53, BCOR, HPGDS POLB 242/4885L3MBTL1 3728/4885TDP1 925/4885
US-20210139897-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS NSUN2, UPF1, RTCB POLB 208/4885L3MBTL1 15/4885TDP1 413/4885
US-20100221214-A1 LINKED DIBENZIMIDAZOLE DERIVATIVES EIF2AK2, NSUN2, ZC3HAV1 POLB 397/4885L3MBTL1 1418/4885TDP1 2549/4885
US-20220127613-A1 Functionally-Modified Oligonucleotides And Subunits Thereof RTCB, NSUN3, NSUN2 POLB 159/4885L3MBTL1 28/4885TDP1 441/4885
US-20110306668-A1 CONSTRUCTION AND SCREENING OF SOLUTION-PHASE DERIVED LIBRARY OF FENBUFEN AND ETHACRYNIC ACID CYP4F2, ACR, CYP4F3 POLB 3051/4885L3MBTL1 1012/4885TDP1 2238/4885
US-11225662-B2 Peptide oligonucleotide conjugates SNRPE, SMN1; SMN2, UPF1 POLB 202/4885L3MBTL1 36/4885TDP1 431/4885
US-20110178066-A1 Hydroxypiperidine derivatives and uses thereof HPGDS, HPGD, DPYD POLB 675/4885L3MBTL1 4206/4885TDP1 371/4885
US-20080045496-A1 PYRROLOTRIAZINE KINASE INHIBITORS JAK2, NTRK2, NTRK3 POLB 1949/4885L3MBTL1 4096/4885TDP1 980/4885
US-20090036429-A1 Hydroxypiperidine Derivatives and Uses Thereof HPGDS, HPGD, DPYD POLB 675/4885L3MBTL1 4206/4885TDP1 371/4885
US-11732259-B2 Peptide oligonucleotide conjugates SNRPE, SMN1; SMN2, UPF1 POLB 202/4885L3MBTL1 36/4885TDP1 431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.