Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 10/20 | 0.41 |
| ▸ | MTTP | P55157 | 9/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974835 | 0.88 | ABCB1 (0.48) | APOBMTTPABCB1TNFNOD2 | |
| SCHEMBL6966580 | 0.87 | SCN9A (0.43) | APOBMTTPABCB1JAK2JAK3 | |
| SCHEMBL6973499 | 0.86 | SMO (0.45) | APOBMTTPABCB1TNFNOD2 | |
| SCHEMBL6967435 | 0.85 | APOB (0.41) | APOBMTTPABCB1TNFNOD2 | |
| SCHEMBL6974444 | 0.85 | KDM4E (0.44) | APOBMTTPABCB1TNFNOD2 | |
| SCHEMBL6974667 | 0.84 | MEN1 (0.49) | APOBMTTPABCB1GAAMAPT | |
| SCHEMBL6964489 | 0.84 | SMO (0.50) | APOBMTTPSMO | |
| SCHEMBL6974297 | 0.84 | CACNA1G (0.51) | APOBMTTPJAK2JAK3PTK2 | |
| SCHEMBL6677620 | 0.84 | APOB (0.41) | APOBMTTPABCB1TNFNOD2 | |
| SCHEMBL6964486 | 0.84 | PLAU (0.46) | APOBMTTPGAAMAPTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |