Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 9/20 | 0.41 |
| ▸ | MTTP | P55157 | 8/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477640 | 0.92 | TACR1 (0.39) | APOBMTTPTACR1JAK2JAK3 | |
| SCHEMBL6966580 | 0.88 | SCN9A (0.43) | APOBMTTPSMOTACR1JAK2 | |
| SCHEMBL6973499 | 0.88 | SMO (0.45) | APOBMTTPSMOJAK2JAK3 | |
| SCHEMBL7041135 | 0.87 | SMO (0.52) | APOBMTTPSMOKDR | |
| SCHEMBL6967435 | 0.86 | APOB (0.41) | APOBMTTPSMOJAK2JAK3 | |
| SCHEMBL6974835 | 0.86 | ABCB1 (0.48) | APOBMTTPABCB1TNFNOD2 | |
| SCHEMBL6964489 | 0.85 | SMO (0.50) | APOBMTTPSMO | |
| SCHEMBL6974297 | 0.85 | CACNA1G (0.51) | APOBMTTPJAK2JAK3PTK2 | |
| SCHEMBL6974444 | 0.85 | KDM4E (0.44) | APOBMTTPSMOJAK2JAK3 | |
| SCHEMBL6688287 | 0.84 | PRMT5 (0.38) | TACR1ABCB1KDRTNFNOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465613-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057205-A2 | COMBINATION OF MTP INHIBITORS OR APOB SECRETION INHIBITORS WITH FIBRATES FOR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-07-17 | — | — | WO | disclosed |