Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 20/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961015 | 0.89 | SIGMAR1 (0.56) | SIGMAR1 | |
| SCHEMBL6966799 | 0.86 | SIGMAR1 (0.56) | SIGMAR1 | |
| SCHEMBL6969178 | 0.85 | SIGMAR1 (0.57) | SIGMAR1 | |
| SCHEMBL6966928 | 0.85 | SIGMAR1 (0.57) | SIGMAR1 | |
| SCHEMBL7300307 | 0.82 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL8799329 | 0.80 | SIGMAR1 (0.77) | SIGMAR1 | |
| SCHEMBL8799851 | 0.80 | SIGMAR1 (0.77) | SIGMAR1 | |
| SCHEMBL6969325 | 0.77 | DRD2 (0.55) | SIGMAR1 | |
| SCHEMBL6967736 | 0.75 | SLC6A4 (0.48) | SIGMAR1 | |
| SCHEMBL6966803 | 0.75 | SLC6A4 (0.48) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964863-B1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 2003-05-21 | — | — | EP | disclosed |
| US-6462056-B1 | SUCH AS 3-(4-CHLOROPHENYL)-5-(4-(3-INDOLYL)-1-PIPERIDINYL-METHYL)OXAZOLIDIN-2-ONE; 5-HT2A ANTAGONISTS WITH 5-HT REUPTAKE INHIBITING, ANTIDEPRESSANT OR ANXIOLYTIC EFFECT | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2002-10-08 | — | — | US | disclosed |
| EP-0964863-A1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GmbH (DE) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998038189-A1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-09-03 | — | — | WO | disclosed |