Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | RHEB | Q15382 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 2/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975492 | 0.94 | HRH4 (0.35) | TDP1VCPMAOBMAOARHEB | |
| SCHEMBL6969238 | 0.91 | VCP (0.38) | TDP1VCPRHEBTACR1HRH4 | |
| SCHEMBL6974526 | 0.88 | TDP1 (0.32) | TDP1ALDH1A1VCPRHEBMMP2 | |
| SCHEMBL7084679 | 0.85 | TDP1 (0.36) | TDP1ALDH1A1 | |
| SCHEMBL6962492 | 0.84 | TLR8 (0.33) | TDP1ALDH1A1MMP2MMP13ADAM17 | |
| SCHEMBL8349607 | 0.82 | TDP1 (0.32) | TDP1 | |
| SCHEMBL6962488 | 0.82 | TDP1 (0.32) | TDP1ALDH1A1MMP2MMP13ADAM17 | |
| SCHEMBL6962017 | 0.82 | TDP1 (0.39) | TDP1ALDH1A1VCPMAOBMAOA | |
| SCHEMBL6974348 | 0.82 | GSK3B (0.34) | TDP1VCPTACR1HRH4HRH3 | |
| SCHEMBL6960981 | 0.82 | TLR8 (0.33) | TDP1ALDH1A1RHEBHRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |