Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | RHEB | Q15382 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | VCP | P55072 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960981 | 0.95 | TLR8 (0.33) | TDP1RHEBTLR8TLR7ALDH1A1 | |
| SCHEMBL8109133 | 0.92 | VCP (0.35) | TDP1RHEBGRM5MMP2MMP13 | |
| SCHEMBL6962492 | 0.89 | TLR8 (0.33) | TDP1TLR8TLR7MMP2MMP13 | |
| SCHEMBL6964734 | 0.88 | TDP1 (0.33) | TDP1RHEBMMP2MMP13ADAM17 | |
| SCHEMBL7084679 | 0.86 | TDP1 (0.36) | TDP1TLR7ALDH1A1 | |
| SCHEMBL14439831 | 0.86 | HDAC1 (0.40) | TDP1RHEBGRM5MMP2MMP13 | |
| SCHEMBL6968588 | 0.84 | MEN1 (0.37) | TDP1ALDH1A1 | |
| SCHEMBL6974348 | 0.84 | GSK3B (0.34) | TDP1TLR8TLR7VCP | |
| SCHEMBL8349607 | 0.84 | TDP1 (0.32) | TDP1TLR7 | |
| SCHEMBL6972834 | 0.84 | TLR8 (0.35) | TDP1TLR8TLR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |